Day: Tuesday 14:45 – 16:30 Room: RB
|
week |
Lerning Outcome |
Focus study |
Topics |
Subtopics |
Learning methods |
Lecturer |
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| 1 start on 7.9.2015 | Understand basic concepts of human genetics | Basic concepts of human genetics | Role of lectureBasic concepts of human genetics
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– | Lecture and discussion | F | |||||
| 2 | Understand Mendelian inheritance patterns of the different types of inheritance patterns of human disease. | Identify and Compare a Mendelian inheritance pattern of different types of inheritance patterns of human disease | Mendelian inheritance pattern of human disease Types of inheritance patterns of human disease | Mendel law, single gene and polygenetics factors Sex-linked, multifactorial and maternal inheritance
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Presentation, Lecture and discussion, student homework | F | |||||
| 3-4 | Understand Gene-environment interaction in behavior related Genomics to the study of complex diseases | Identifify Gene-environment interaction in behavior related Genomics to the study of complex diseases | Mapping and characterizing “complex” genetic diseases | Genomics for the study of complex diseases, genetic study of type 2 diabetes and obesity, Gene-environment interaction in behavior, pharmacogenetics | Presentation, Lecture and discussion | F | |||||
| 5-6 | Understanding gene inheritance: Genes to proteins to traits | Identify Gene to protein synthesis | Transcription, post-transcription (mRNA maturation) and translation , post-translation (functional protein modification) | how a gene provides the instructions for making a protein and how genes can cause albinism or sickle cell anemia or other disease | Presentation, Lecture and discussion
student homework |
WN | |||||
| 6-8 | Understand multigenic inheritance patterns. | Identify a multigenic inheritance pattern. | Mapping and characterizing “simple” genetic disease | Mapping disease genes, disease-associated mutations, diseases associated with a gene loss-function effect, nuclear and mitochondrial genome mutations, Evolution of a gene cluster and divergence of function | Presentation, Lecture and discussion
student homework |
WN | |||||
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MIDDLE SEMESTER EXAMINATION |
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| 9-10 | Understand the current research into epigenetic and transgenerational inheritance. | Explain the basics of epigenetic and transgenerational inheritance. | Sex, prions, and epigenetics | Epigenetic inheritance of chromatin states / Role of DNA methylation in human disease,dysregulation of the histone modification machinery, transgenerational epigenetic inheritance, sex determination, prion diseases | Presentation, Lecture and discussion
student homework |
WN | |||||
| 11-12 | Understand how to interpret data from a genome-wide association (GWA) study and Genetic Testing | Analyze data from genome-wide association studies. | Genome-wide association (GWA) study and Genetic Testing | Genome-wide association (GWA) studyType, across the life span (prenatal, pediatric and adult), technology, molecular, clinical and ethical perspectives | Presentation, Lecture and discussion
student homework |
WN | |||||
| 13 | Understand Chromosomal and genomic disorders | Identify Chromosomal and genomic disorders | Chromosomal and genomic disorders | Mechanisms and maternal age influence the origin of aneuploidy in humans, mechanisms causing these aberrations, fragile X syndrome | Presentation, Lecture and discussion
student homework |
F | |||||
| 14 | Understand the potential implications of personalized and genomic medicine | Explain the potential benefits and risks/challenges of genomic medicine. | Natural genetics resources: the potential benefits and risks/challenges | Pharcogenenomic and/orNutrigenomic:
Bioactive compound, phytopharmaca, functional food for healthy controlling |
Presentation, Lecture and discussion
student homework |
F | |||||
| 15 | Understand some of the ethical issues facing genomic researchers. | Explain some of the ethical challenges raised by the prevalence of genomic data | Medical genetics and the associated ethical, legal, and social implications | Ethical clearanceInform consent
ELSI for medical research based on samples of human or animal model |
Presentation, Lecture and discussion | F | |||||
Lecturer: F (Prof. Fatchiyah, PhD) and WN (Prof. Wolfgang Nellen)
Daftar Pustaka
Rick Lewis. 2011. Basic Human Genetics. Routledge Taylor & Francis group, NY · ISBN-10: 0415579864 · ISBN-13: 978-0415579865,
Ricki Lewis. 2011. Human Genetics concepts and application. McGraw-Hill Education; 10 edition ISBN-13: 978-0073525303, ISBN-10: 0073525308 or ISBN: 007246268x
Tom Strachan & Andrew Read.2003. Human Molecular genetics. Garland Science; 3 edition. · ISBN-10: 0815341822 · ISBN-13: 978-0815341826
Julian Knight.2009. Human Genetic Diversity. Oxford Univrsity Press. London.
Robert Nussbaum, Roderick R. McInnes, and Huntington F Willard. 2007. Genetics in Medicine, 7th Edition. Sounders. · ISBN: 9781416030805
John Quackenbush. 2011. The Human Genome: Book of Essential Knowledge. ISBN-13: 978-1936140152
Bruce R. Korf and Mira B. Irons. 2013. Human Genetics and Genomics. 4th Edition. Wiley-Blackwell. ISBN-10: 0470654473; ISBN-13: 978-0470654477