Lecture : Genetics

Genetics course syllabus

 

This course consist of  Cytogenetics, Mendelian Genetics, Advanced Genetics dan Molecular Genetics.

 

Learning Outcomes for Cytogenetics
After completion of this course the student will be able to:

  1. list and identify the stages of mitosis and meiosis, as well as the cell cycle, and explain the significance of each.
  2. compare and contrast mitosis and meiosis with particular attention to chromosome movements and definitions of haploid and diploid.
  3. understand the basic structure and function of chromosomes and how they relate to medicine and evolution.
  4. compare and contrast sexual and asexual reproduction as well understand alternation of generations.

Learning Outcomes for Mendelian Genetics
After completion of this course the student will be able to:

  1. understand Mendel’s first and second laws and how they relate to cytogenetics.
  2. predict the outcome of crosses including the use of the Punnett square.
  3. apply chi square analysis to those predictions.
  4. design and explain an experiment that uses test crosses to determine genotypes.

Learning Outcomes for Advanced Genetics
After completion of this course the student will be able to:

  1. explain the chromosomal basis of sex determination and apply that understanding to predict the sex of individuals with normal and abnormal complements of sex chromosomes.
  2. define sex-linked characteristics and describe their transmission.
  3. differentiate between sex-linked and sex-influenced characteristics.
  4. compare and contrast incomplete dominance and co-dominance and predict their modes of inheritance.
  5. describe and explain multiple alleles, multiple loci and multiple effects of a single gene.
  6. understand the basis for cytoplasmic inheritance and how it differs from Mendelian genetics.
  7. draw and use pedigrees to display and understand the pattern of single gene inheritance as well as predict relatedness.
  8. analyze a population using the Hardy-Weinberg calculations.

Learning Outcomes for Molecular Genetics
After completion of this course the student will be able to:

  1. describe the basis upon which we link molecular genetics to earlier (non-molecular) genetics.
  2. describe and understand the structure of DNA and RNA, their “subunits” and how they differ.
  3. describe how DNA is duplicated, how DNA is transcribed into RNA and how RNA is translated into proteins.
  4. understand the Genetic Code and how to translate a nucleic acid sequence into an amino acid sequence.
  5. understand the structure and details of prokaryotic DNA duplication including details of DNA polymerase.
  6. describe the three ways bacteria can exchange genes as well as understand restriction endonucleases.
  7. understand the details of transcription control in prokaryotes as illustrated by three different operons.
  8. understand the molecular structure of eukaryotic chromosomes and repetitive DNA.
  9. provide an overview of viruses that infect eukaryotes.
  10. understand eukaryotic transcription control via the participating transcription factors, promoters and silencers.
  11. appreciate the various types of genes and control mechanisms in eukaryotes.
  12. understand methylation and its function in chromosome inactivation and gene imprinting.
  13. describe eukaryotic posttranscriptional processing, initiation of translation and posttranslational modifications.
  14. contrast and compare the molecular genetics (structure and control) of prokaryote versus eukaryote genes.

 

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