Phylogenetic reconstruction is a fast-growing field that is enriched by different statistical approaches and by findings  and  applications  in  a  broad  range  of  biological  areas.  Fundamental  to  these  are  the  mathematical models used to describe the patterns of DNA base substitution and amino acid replacement. These may become some of the basic models for comparative genome research. We discuss these models, including the analysis of observed DNA base and amino acid mutation patterns, the concept of site heterogeneity, and the incorporation of structural biology data, all of which have become particularly important in recent years. We also describe the use  of  such  models  in  phylogenetic  reconstruction  and  statistical  methods  for  the  comparison  of  different models.

Detail article …Models_Molecular_Evolution

ppt mol evolution Ch10_MolEvolution ppt